In patients treated with edex® for up to 24 months, local bleeding, hematoma, and ecchymosis were observed in 15%, 5%, and 4% of patients, respectively. On a per injection basis, 15% of injections were associated with penile pain. Your exact dose will be determined by your doctor. Use of intracavernous edex® offers no protection from the transmission of sexually transmitted or blood-borne diseases. Adobe Acrobat Reader is required to read PDFs. Small amounts of bleeding at the injection site can increase the risk of transmission of blood-borne diseases between partners. The edex® cartridge contains a solid layer or lyophilized cake of dry white powder approximately 3/8" in thickness. Alprostadil (PGE1) is one of the prostaglandins, a family of naturally occurring acidic lipids with various pharmacological effects. Immediately apply firm but gentle pressure with the alcohol swab to the injection site for five minutes to prevent bruising (Figure O). Study 1: One hundred fourteen men with a mean age of 53 years (range 22 to 65 years) were enrolled in the first phase. Not all photos of the drug may be displayed. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Long-term carcinogenicity studies have not been conducted. The ridge on the cartridge will need to fit into the groove on the injection device. The lowest effective dose should be used at home. Attach the needle to the tip of the edex® injection device by turning clockwise until tight (Figure C). After reconstitution, the edex® injection device is used to administer the intracavernous injection of alprostadil. The other chamber contains 1.075 mL of sterile 0.9% sodium chloride. This leaflet provides a summary of information about your medicine. A small amount of bleeding at the injection site may occur. Carefully place the large external protective cap on the needle. © 2020 Kaiser Foundation Health Plan, Inc. Kaiser Permanente health plans around the country: Kaiser Foundation Health Plan, Inc., in Northern and Southern California and Hawaii • Kaiser Foundation Health Plan of Colorado • Kaiser Foundation Health Plan of Georgia, Inc., Nine Piedmont Center, 3495 Piedmont Road NE, Atlanta, GA 30305 • Kaiser Foundation Health Plan of the Mid-Atlantic States, Inc., in Maryland, Virginia, and Washington, D.C., 2101 E. Jefferson St., Rockville, MD 20852 • Kaiser Foundation Health Plan of the Northwest, 500 NE Multnomah St., Suite 100, Portland, OR 97232 • Kaiser Foundation Health Plan of Washington or Kaiser Foundation Health Plan of Washington Options, Inc., 601 Union St., Suite 3100, Seattle, WA 98101. Geriatric patients should be dosed and titrated according to the same DOSAGE AND ADMINISTRATION recommendations as younger patients, and the lowest possible effective dose should always be used. During the subsequent two-week double-blind, cross-over phase, patients self-injected edex® or placebo at home. Four patients (<1%) reported clinical symptoms of hypotension such as dizziness or syncope. (alprostadil for injection) If you have questions, ask your pharmacist. There are several causes of erectile dysfunction, commonly known as impotence. The edex® cartridges contain a solid layer or cake of dry white powder approximately 3/8” in thickness. If there is a response, then there should be at least a 1-day interval before the next dose is given. The human dose of edex® is <1 mcg/kg (MRHD is 40 mcg and the calculation assumes a 60-kg subject). There were no clinically important changes or trends in pharmacodynamic parameters for these drugs. Dosage is based on your medical condition and response to therapy. With use of up to 24 months, penile pain was reported at least once by 29% of patients during injection, 35% of patients during erection, and by 30% of patients after erection. It is more expensive than trimix but you may just use it for this trip. US residents can call their local poison control center at 1-800-222-1222. Access Coupon. Not all photos of the drug may be displayed. Do not use the cartridge if it appears damaged or the cake is substantially reduced in size. Caverject is an injectable medication used to treat erectile dysfunction by directing blood flow to the penis. 6. Unlike the 15-keto metabolites which are less pharmacologically active than the parent compound, PGE0 is similar in potency to PGE1 in vitro using isolated animal organs. The edex® cartridges are supplied in the following packages: Store at 25°C (77°F); excursions permitted between 15°C - 30°C (59°F - 86°F). edex® Cartridge 2 Pack contains one reusable edex® injection device, two single-dose, dual-chamber cartridges, two ½-inch, 29-gauge (0.33 mm × 12.7 mm) needles, and four alcohol swabs. As with any drug product, extremes in temperature should be avoided. Set the injection device down on a clean, level surface and do not allow the needle to touch anything. Canada residents can call a provincial poison control center. The incidence of priapism (erections greater than 6 hours in duration) was <1% with long-term use for up to 24 months. IMPORTANT: To maintain sterility and avoid contamination, follow these directions carefully. Note: Individuals who are sexually active should be counseled about the protective measures that are necessary to guard against the spread of sexually transmitted diseases, including the human immunodeficiency virus (HIV). In a study in symptomatic subjects with impaired hepatic function and age/weight/sex-matched healthy volunteers, 120 mcg of alprostadil was administered by intravenous infusion over 2 hours. The physician should make a careful assessment of the patient's skills and competence with the self-injection procedure. Call the prescribing physician or, if unavailable, seek professional help immediately if you still have an erection 6 hours after injection. Careful and continuous follow-up of the patient while in the self-injection program must be exercised. 6) edex® uses a superfine (29 gauge) needle. 98. Do not touch the exposed needle or allow the needle to touch anything. If you don't get the ache from the drug it should be a go for you. If the dosage prescribed is less than 1 mL of edex® solution, excess solution will be expelled through the needle as the plunger is pushed and the upper rim of the top stopper reaches the correct volume mark for the prescribed dose. edex® should not be used by women or children. 2. edex® solution should be used immediately after reconstitution. There is no approved injectable treatment using multiple medications. Last updated on Jul 22, 2020. Your medication may look different. The recommended frequency of injection is no more than 3 times weekly, with at least 24 hours between each dose. penile bypass or implants), hormone treatment, psychological counseling, lifestyle changes, or a change in medication. According to the Cleveland Clinic, as many as 52% of men experience erectile dysfunction, with it affecting 40% of men age 40, and 70% of men age 70. Patients should be instructed to report to the physician any penile redness, swelling, tenderness or curvature of the erect penis. Use only the dose prescribed by your doctor. Do not use the solution if it remains cloudy, is colored, or contains particles. The pharmacokinetic and pharmacodynamic interaction between alprostadil intravenous infusion, 90 mcg over 3 hours, and heparin (5,000 IU) was evaluated in 12 healthy volunteers. 21. Estimated Cash Price $ 208. Among the 60% (139/233) of patients who entered the open-label treatment phase, the mean rate of response with an erection sufficient for intercourse was 85.3% through six months. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Prices start at $179.73 Hold the injection device in an upright position with the needle pointing up. For further information or advice, ask your doctor or pharmacist. Pick up the injection device and reposition the penis as in Step 14 to keep it from moving during the injection. Thereafter, patients continued to perform self-injections of open-label edex® for six or 12 months, and the occurrence of an erection sufficient for sexual intercourse was documented following each injection. If the cartridge is damaged, the cake may shrink in size. Compare prices, print coupons and get savings tips for Edex () and other Erectile Dysfunction drugs at CVS, Walgreens, and other pharmacies. A potentially serious adverse reaction with intracavernous therapy is priapism. Store at 25°C (77°F); temperature variations between 15°C - 30°C (59°F - 86°F) are allowed. Pregnancy, Nursing Mothers and Pediatric Use. edex® Cartridge 6 Pack contains one reusable edex® injection device, six single-dose, dual-chamber cartridges, six ½-inch, 29-gauge (0.33 mm × 12.7 mm) needles, and twelve alcohol swabs. 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